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Well-differentiated liposarcoma

MedGen UID:
237164
•Concept ID:
C1370889
•
Neoplastic Process
Synonyms: Atypical Lipomatous Tumor; Atypical Lipomatous Tumors; Lipomatous Tumor, Atypical; Liposarcoma, Well Differentiated; Well Differentiated Liposarcoma; Well Differentiated Liposarcomas
SNOMED CT: Liposarcoma - differentiated (28655007); Liposarcoma - well differentiated (28655007); Liposarcoma, well differentiated (28655007); Liposarcoma, differentiated (28655007); Well differentiated liposarcoma (1290827008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005103
Orphanet: ORPHA99971

Definition

Well-differentiated liposarcoma (WDLS), the most common type of liposarcoma (LS; see this term), is a slow growing, painless tumor usually located in the retroperitoneum or the limbs. It is composed of proliferating mature adipocytes. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell-differentiated liposarcoma
Follow this link to review classifications for Well-differentiated liposarcoma in Orphanet.

Professional guidelines

PubMed

Well-differentiated liposarcomas and dedifferentiated liposarcomas: Systemic treatment options for two sibling neoplasms.
Kyriazoglou A, Pagkali A, Kotsantis I, Economopoulou P, Kyrkasiadou M, Moutafi M, Gavrielatou N, Anastasiou M, Boulouta A, Pantazopoulos A, Giannakakou M, Digklia A, Psyrri A
Cancer Treat Rev 2024 Apr;125:102716. Epub 2024 Mar 11 doi: 10.1016/j.ctrv.2024.102716. PMID: 38492514
Established and Experimental Systemic Treatment Options for Advanced Liposarcoma.
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Management of Recurrent Retroperitoneal Sarcoma.
Jolissaint JS, Raut CP, Fairweather M
Curr Oncol 2023 Feb 25;30(3):2761-2769. doi: 10.3390/curroncol30030209. PMID: 36975422Free PMC Article
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature.
Kang JY, Kim HJ, Wojno TH, Yeung AM, Mendoza PR, Grossniklaus HE
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S134-S140. doi: 10.1097/IOP.0000000000001804. PMID: 32991496
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Surgery for Abdominal Well-Differentiated Liposarcoma.
Mansfield SA, Pollock RE, Grignol VP
Curr Treat Options Oncol 2018 Jan 16;19(1):1. doi: 10.1007/s11864-018-0520-6. PMID: 29335908
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

Sarcoma care in the era of precision medicine.
Wallander K, Öfverholm I, Boye K, Tsagkozis P, Papakonstantinou A, Lin Y, Haglund de Flon F
J Intern Med 2023 Dec;294(6):690-707. Epub 2023 Sep 7 doi: 10.1111/joim.13717. PMID: 37643281
Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma.
Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.
Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045
Clinical and Molecular Spectrum of Liposarcoma.
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article

Therapy

Well-differentiated liposarcomas and dedifferentiated liposarcomas: Systemic treatment options for two sibling neoplasms.
Kyriazoglou A, Pagkali A, Kotsantis I, Economopoulou P, Kyrkasiadou M, Moutafi M, Gavrielatou N, Anastasiou M, Boulouta A, Pantazopoulos A, Giannakakou M, Digklia A, Psyrri A
Cancer Treat Rev 2024 Apr;125:102716. Epub 2024 Mar 11 doi: 10.1016/j.ctrv.2024.102716. PMID: 38492514
Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
Established and Experimental Systemic Treatment Options for Advanced Liposarcoma.
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Surgery for Abdominal Well-Differentiated Liposarcoma.
Mansfield SA, Pollock RE, Grignol VP
Curr Treat Options Oncol 2018 Jan 16;19(1):1. doi: 10.1007/s11864-018-0520-6. PMID: 29335908
Managing Liposarcomas: Cutting Through the Fat.
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163

Prognosis

Sarcoma care in the era of precision medicine.
Wallander K, Öfverholm I, Boye K, Tsagkozis P, Papakonstantinou A, Lin Y, Haglund de Flon F
J Intern Med 2023 Dec;294(6):690-707. Epub 2023 Sep 7 doi: 10.1111/joim.13717. PMID: 37643281
Retroperitoneal and Mesenteric Liposarcomas.
Siew CCH, Apte SS, Baia M, Gyorki DE, Ford S, van Houdt WJ
Surg Oncol Clin N Am 2022 Jul;31(3):399-417. doi: 10.1016/j.soc.2022.03.005. PMID: 35715141
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Molecular updates in adipocytic neoplasms(✰).
Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767
Clinical and Molecular Spectrum of Liposarcoma.
Lee ATJ, Thway K, Huang PH, Jones RL
J Clin Oncol 2018 Jan 10;36(2):151-159. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9598. PMID: 29220294Free PMC Article

Clinical prediction guides

GLI1 Coamplification in Well-Differentiated/Dedifferentiated Liposarcomas: Clinicopathologic and Molecular Analysis of 92 Cases.
Sharma AE, Dickson M, Singer S, Hameed MR, Agaram NP
Mod Pathol 2024 Jun;37(6):100494. Epub 2024 Apr 15 doi: 10.1016/j.modpat.2024.100494. PMID: 38621503Free PMC Article
Sarcoma care in the era of precision medicine.
Wallander K, Öfverholm I, Boye K, Tsagkozis P, Papakonstantinou A, Lin Y, Haglund de Flon F
J Intern Med 2023 Dec;294(6):690-707. Epub 2023 Sep 7 doi: 10.1111/joim.13717. PMID: 37643281
Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
The molecular landscape of well differentiated retroperitoneal liposarcoma.
Tyler R, Dilworth MP, James J, Blakeway D, Stockton JD, Morton DG, Taniere P, Gourevitch D, Desai A, Beggs AD
J Pathol 2021 Oct;255(2):132-140. Epub 2021 Aug 4 doi: 10.1002/path.5749. PMID: 34156092
Dedifferentiated liposarcoma.
Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):263-6. PMID: 11757866

Recent systematic reviews

Surgical management of truncal and extremities atypical lipomatous tumors/well-differentiated liposarcoma: A systematic review of the literature.
Choi KY, Jost E, Mack L, Bouchard-Fortier A
Am J Surg 2020 May;219(5):823-827. Epub 2020 Jan 28 doi: 10.1016/j.amjsurg.2020.01.046. PMID: 32029218
Atypical Lipomatous Tumors: Does Our Inconsistent Terminology Have Patient Repercussions? Results of a Meta-Analysis.
Fourman MS, van Eck CF, Weiss KR, Goodman MA, McGough RL
Am J Clin Oncol 2019 May;42(5):487-492. doi: 10.1097/COC.0000000000000540. PMID: 30932920
Retroperitoneal Liposarcoma: A Concern in Inguinal Hernia Repair.
Lechner M, Borhanian K, Mitterwallner S, Bittner R, Klieser E, Köhler G, Emmanuel K, Mayer F
JSLS 2019 Jan-Mar;23(1) doi: 10.4293/JSLS.2018.00064. PMID: 30700965Free PMC Article
Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

    Reviews

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